Thrombotic antiphospholipid syndrome

Rivaroxaban to treat thrombotic antiphospholipid syndrome.

Thrombosis is one of the clinical hallmarks of antiphospholipid syndrome, a heterogeneous autoimmune disorder associated with the presence of antiphospholipid antibodies. Thrombosis can occur in any vascular bed, but most patients present with venous thrombosis or ischaemic stroke. Patients with antiphospholipid syndrome have a high risk of recurrent thrombotic events. The standard treatment fo...

Thrombotic microangiopathic haemolytic anaemia and antiphospholipid antibodies.

OBJECTIVE To analyse the clinical and laboratory features of patients with thrombotic microangiopathic haemolytic anaemia (TMHA) associated with antiphospholipid antibodies (aPL). METHODS A computer assisted (PubMed) search of the literature was performed to identify all cases of TMHA associated with aPL from 1983 to December 2002. RESULTS 46 patients (36 female) with a mean (SD) age at pre...

Anticardiolipin syndrome: antiphospholipid syndrome.

North Am 2000;26:215–27. 14 Savill J. Recognition and phagocytosis of cells undergoing apoptosis. Br Med Bull 1997;53:491–508. 15 Elkon KB. Apoptosis in SLE – too little or too much? Review. Clin Exp Rheumatol 1994;12:553–9. 16 Drappa J, Vaishnaw AK, Sullivan KE, Chu JL, Elkon KB. Fas gene-mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmu...

Antiphospholipid syndrome

APS can be primary or secondary. Primary antiphospholipid syndrome occurs in the absence of any other related disease. Secondary antiphospholipid syndrome is often associated with systemic lupus erythematosus and less frequently with infections, drugs and other diseases. Serologic markers are antiphospholipid antibodies, lupus anticoagulant and anticardiolipin. In rare cases, APS leads to rapid...

Antiphospholipid syndrome